GSK J1
- Product Name
- GSK J1
- CAS No.
- 1373422-53-7
- Chemical Name
- GSK J1
- Synonyms
- GSK-J1;GSK J1;GCK J1;CS-2305;Histone demethylase inhibitor J1;Histone Lysine Demethylase Inhibitor VII, GSK-J1;Histone Lysine Demethylase Inhibitor VII, GSK-J1 - CAS 1373422-53-7 - Calbiochem;N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyriMidinyl]-|-alanine;β-Alanine, N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-;N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine
- CBNumber
- CB72668658
- Molecular Formula
- C22H23N5O2
- Formula Weight
- 389.45
- MOL File
- 1373422-53-7.mol
GSK J1 Property
- Boiling point:
- 608.9±55.0 °C(Predicted)
- Density
- 1.292±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble15mg/mL, clear
- form
- powder
- pka
- 4.20±0.10(Predicted)
- color
- white to beige
- Stability:
- Stable for 2 years from date of purchase? as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- InChIKey
- AVZCPICCWKMZDT-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0709
- Product name
- GSK-J1
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $78
- Updated
- 2024/03/01
- Product number
- SML0709
- Product name
- GSK-J1
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $191.2
- Updated
- 2024/03/01
- Product number
- 4593
- Product name
- GSKJ1
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $216
- Updated
- 2021/12/16
- Product number
- 4593
- Product name
- GSKJ1
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $891
- Updated
- 2021/12/16
- Product number
- 451480
- Product name
- GSK J1
- Packaging
- 10mg
- Price
- $460
- Updated
- 2021/12/16
GSK J1 Chemical Properties,Usage,Production
Description
GSK-J1 (1373422-53-7) is a potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such GSK-J1 is useful as a standard in in vitro assays. A cell permeable ethyl ester analog is also available, see GSK-J4 (cat.# 10-1394).
Uses
GSK J1 is a selective and potent inhibitor of JMJDE and UTX demethylases.
Definition
ChEBI: 3-[[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)-4-pyrimidinyl]amino]propanoic acid is an organonitrogen heterocyclic compound.
Biochem/physiol Actions
GSK-J1 is also termed as 3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate. It may disturb the differentiation of specific neuronal subtypes in growing rat retina.
storage
room temperature (desiccate)
References
1) Kruidenier et al. (2012), A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response; Nature, 488 404
GSK J1 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK J1 Suppliers
View Lastest Price from GSK J1 manufacturers
- Product
- GSK J1 1373422-53-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-08-29
- Product
- GSK-J1 1373422-53-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10